Deriglidole 是外周肾上腺素能受体拮抗剂，对 α<sub>2</sub> 肾上腺素受体具有高亲和力。<BR><a href="https://www.medchemexpress.cn/Ibrutinib-biotin.html">Ibrutinib-biotin</a>产品描述：Ibrutinib-biotin is a probe that consists of Ibrutinib linked to biotin via a long chain linker, extracted from patent WO2014059368A1 Compound 1-5, has an <b>IC<sub>50</sub></b> of 0.755-1.02 nM for <b>BTK</b>.
IC50 & Target: IC50: 0.755-1.02 nM (BTK), 1.71-2.29 nM (TEC), 3.66-4.27 nM (BLK), 4.42-5.57 nM (BMX), 5.99-6.92 nM (LCK), 33.8-36.3 nM (Src), 0.187-0.198 μM (ITK),5.34-4.87 μM (JAK3)<sup>[1]</sup>
<i><b>In Vitro:</b></i> Ibrutinib-biotin (Compound 1-5) is a probe that consists of Ibrutinib linked to biotin via a long chain linker. Ibrutinib is a TEC family kinase inhibitor. The TEC kinase family is composed of five members, TEC, BTK (Bruton's Tyrosine Kinase), ITK (interleukin-2-inducible T-cell kinase)/EMT/TSK, BMX and TXK/RLK. The TEC family kinases participate in phosphotyrosine- mediated and phospholipid-mediated signaling systems. Many TEC family proteins are abundantly expressed in hematopoietic tissues, and play important roles in the growth and differentiation process<br><br>
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已为全球多个知名企业、院校构建各种定制型化合物库。</span><br><br>产品链接：<a href="http://www.medchemexpress.cn/Ibrutinib-biotin.html">www.medchemexpress.cn/Ibrutinib-biotin.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"
src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"
alt="">Purity:98%<BR>MWt:255.3580<BR>Formula:C16H21N3<BR>SMILES:CCCC1(C2=NCCN2)N3C4=C(C=CC=C4CC3)C1<BR>Pathway:GPCR/G Protein; <BR>Mechanisms:Adrenergic Receptor; <BR>Research Area:metabolic Disease<BR>电话： 021-58955995<BR>网址： www.MedChemExpress.cn <BR>地址： 上海市浦东新区蔡伦路720号2号楼3层
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