Setipafant 是一种血小板活化因子 (<b>PAF</b>) 拮抗剂。<BR><a href="https://www.medchemexpress.cn/Nutlin-3a.html">Nutlin (3a)</a>产品描述：Nutlin (3a) is a murine double minute (<b>MDM2</b>) antagonist that inhibits <b>MDM2-p53</b> interactions and stabilizes the p53 protein, thereby inducing cell cycle arrest and apoptosis.
IC50 & Target: MDM2-p53<sup>[1]</sup>
<i><b>In Vitro:</b></i> Nutlin-3a is a therapeutic which inhibits MDM2, activates wild-type p53, and induces apoptosis-as a therapeutic compound for <i>TP53</i> wild-type ovarian carcinomas. Three cell lines (HOC-7, OVCA429 and A2780) with wild-type <i>TP53</i> are highly sensitive to Nutlin-3a (IC<sub>50</sub>=4 to 6 μM). SKOV3 cells have an IC<sub>50</sub> of 38 μM to Nutlin-3a. The two remaining ovarian clear cell lines (TOV21G and OVAS), both with <i>TP53</i> wild-type, are relatively more sensitive to growth inhibition with Nutlin-3a (IC<sub>50</sub>=14 and 25 μm respectively) than the <i>TP53</i> mutant cell lines<sup>[1]</sup>. Nutlin-3a is the active enantiomer of Nutlin-3. Nutlin-3a is a highly selective MDM2 antagonist and p53 inducer. Seven days of<br><br>
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已为全球多个知名企业、院校构建各种定制型化合物库。</span><br><br>产品链接：<a href="http://www.medchemexpress.cn/Nutlin-3a.html">www.medchemexpress.cn/Nutlin-3a.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"
src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"
alt="">Purity:98%<BR>MWt:519.0178<BR>Formula:C26H23ClN6O2S<BR>SMILES:O=C(N(C1)CCC2=C1SC3=C2C(C4=CC=CC=C4Cl)=NCC5=NN=C(C)N53)NC6=CC=C(OC)C=C6<BR>Pathway:Others; <BR>Mechanisms:Others; <BR>Research Area:Cardiovascular Disease<BR>电话： 021-58955995<BR>网址： www.MedChemExpress.cn <BR>地址： 上海市浦东新区蔡伦路720号2号楼3层
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