Tiapamil hydrochloride 是一种钙离子 (<b>Calcium channel</b>) 阻断剂。<BR><a href="https://www.medchemexpress.cn/SZL-P1-41.html">SZL P1-41</a>产品描述：SZL P1-41 is Skp2 inhibitor, selectively suppresses Skp2 E3 ligase activity, but not activity of other SCF complexes.
target: Skp2
In vitro: SZL P1-41 also phenocopies the effects observed upon genetic Skp2 deficiency, such as suppressing survival, Akt-mediated glycolysis as well as triggering p53-independent cellular senescence. SZL P1-41 prevent Skp2-Skp1 interactions and Skp2 SCF E3 ligase activity. The reference concentration is 5 uM. SZL P1-41 restricts cancer cell survival through triggering p53-independent cellular senescence and inhibiting aerobic glycolysis.
In vivo: SZL P1-41 exhibits potent anti-tumor activities in multiple animal models and cooperates with chemotherapeutic agents to reduce cancer cell survival.
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已为全球多个知名企业、院校构建各种定制型化合物库。</span><br><br>产品链接：<a href="http://www.medchemexpress.cn/SZL-P1-41.html">www.medchemexpress.cn/SZL-P1-41.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"
src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"
alt="">Purity:98%<BR>MWt:592.1648<BR>Formula:C26H38ClNO8S2<BR>SMILES:CN(CCC1=CC=C(OC)C(OC)=C1)CCCC(S(CCC2)(=O)=O)(C3=CC=C(OC)C(OC)=C3)S2(=O)=O.[H]Cl<BR>Pathway:Membrane Transporter/Ion Channel; <BR>Mechanisms:Calcium Channel; <BR>Research Area:Cardiovascular Disease<BR>电话： 021-58955995<BR>网址： www.MedChemExpress.cn <BR>地址： 上海市浦东新区蔡伦路720号2号楼3层
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