Sulamserod 是一种 <b>5-HT4 receptor</b> 拮抗剂，具有抗心律失常的功效。<BR><a href="https://www.medchemexpress.cn/DREADD-agonist-21.html">DREADD agonist 21</a>产品描述：DREADD agonist 21 is a potent human muscarinic acetylcholine M3 receptors (<b>hM3Dq</b>) agonist(<b>EC<sub>50</sub></b>=1.7 nM).
IC50 & Target: EC50: 1.7 nM (hM3Dq)<sup>[1]</sup><br/>Ki: 6 nM (H1 histamine receptor), 66 nM (5HT2A serotonin receptor 5HT2A), 170 nM (5HT2C serotonin receptor), 280 nM (α1A adrenergic receptor)<sup>[1]</sup>
<i><b>In Vitro:</b></i> DREADD agonist 21 is a potent human muscarinic acetylcholine M3 receptors (hM3Dq) agonist (EC<sub>50</sub>=1.7 nM) and does not activate human M3 receptor (hM3). In addition to being inactive at hM3, DREADD agonist 21, a potent full agonist of hM3Dq (EC<sub>50</sub>=1.7 nM), is only 3.5-fold selective for hM3Dq over H1, 40-fold selective over 5HT2A, 100-fold selective over 5HT2C, and 165-fold selective over α1A. DREADD agonist 21 shows high binding affinities to 5HT2A and 5HT2C serotonin receptor, α1A adrenergic receptor, and H1 histamine receptor with K<sub>i</sub> values of 66, 170, 280, and 6 nM, respectively<sup>[1]</sup><br><br>
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已为全球多个知名企业、院校构建各种定制型化合物库。</span><br><br>产品链接：<a href="http://www.medchemexpress.cn/DREADD-agonist-21.html">www.medchemexpress.cn/DREADD-agonist-21.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"
src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"
alt="">Purity:98%<BR>MWt:445.9607<BR>Formula:C19H28ClN3O5S<BR>SMILES:CS(=O)(NCCN1CCC(CCC(C2=C3OCCOC3=C(N)C(Cl)=C2)=O)CC1)=O<BR>Pathway:GPCR/G Protein; Neuronal Signaling; <BR>Mechanisms:5-HT Receptor; <BR>Research Area:Cardiovascular Disease<BR>电话： 021-58955995<BR>网址： www.MedChemExpress.cn <BR>地址： 上海市浦东新区蔡伦路720号2号楼3层
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