Pargolol hydrochloride 是 β 肾上腺素能受体 (<b>adrenergic receptor</b>) 拮抗剂。<BR><a href="https://www.medchemexpress.cn/SKF89976A-hydrochloride.html">SKF89976A (hydrochloride)</a>产品描述：SKF89976A hydrochloride is a selective <b>GABA transporter</b> (<b>GAT-1</b>) inhibitor with <b>IC<sub>50</sub></b>s of 0.28 μM, 137.34 μM and 202.8 μM for GAT-1, GAT-2 and GAT-3 in CHO cells, respectively.
IC50 & Target: IC50: 0.28 μM (GAT-1), 137.34 μM (GAT-2), 202.8 μM (GAT-3)<sup>[1]</sup>
<i><b>In Vitro:</b></i> SKF89976A has a weak antiallodynic action. SKF89976A weakly inhibits serotonin transporter (SERT), noradrenaline transporter (NET), and dopamine transporter (DAT) in chinese hamster ovary (CHO) cells stably expressing each transporter using a substrate uptake assay, with IC<sub>50</sub></b> values of 3514 , 202.13, and 728.8, respectively<sup>[1]</sup>. SKF89976A is a GABA-transport blocker. GABA (1 mM) elicited an inward current that is completely suppressed by the GABA transport inhibitors tiagabine (10 μM) and SKF89976A (100 μM), but is unaffected by 100 μM picrotoxin. 100 μM SKF 89976-A is known to block the transport of GABA into cells, completely eliminated the GA<br><br>
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已为全球多个知名企业、院校构建各种定制型化合物库。</span><br><br>产品链接：<a href="http://www.medchemexpress.cn/SKF89976A-hydrochloride.html">www.medchemexpress.cn/SKF89976A-hydrochloride.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"
src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"
alt="">Purity:98%<BR>MWt:313.8197<BR>Formula:C16H24ClNO3<BR>SMILES:OC(COC1=CC=CC=C1OCC#C)CNC(C)(C)C.[H]Cl<BR>Pathway:GPCR/G Protein; <BR>Mechanisms:Adrenergic Receptor; <BR>Research Area:Neurological Disease<BR>电话： 021-58955995<BR>网址： www.MedChemExpress.cn <BR>地址： 上海市浦东新区蔡伦路720号2号楼3层
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