COX2-IN-1是选择性的，诱导型的 <b>COX2</b> 抑制剂，<b>IC<sub>50</sub></b> 值为0.24 μM。COX2-IN-1是具有抗炎和止痛活性的抗炎物。<BR><a href="https://www.medchemexpress.cn/CZ415.html">CZ415</a>产品描述：CZ415 is a potent and highly selective <b>mTOR</b> inhibitor.
IC50 & Target: mTOR<sup>[1]</sup><br/>
IC50: 14.5 nM (pS6RP), 14.8 nM (pAKT), 226 nM (IFNγ)<sup>[1]</sup>
<i><b>In Vitro:</b></i> Inhibition of phosphorylation for both downstream targets results in 14.5 nM IC<sub>50</sub> for pS6RP and 14.8 nM for pAKT. The immunosuppressive effect of CZ415 is measured by detecting secreted IFNγ after 18 hours in stimulated human whole blood and the resulting IC<sub>50</sub> is 226 nM. As a predictor for cardiotoxicity, the activity of CZ415 against the human cardiac ion channel hERG is assessed in a whole-cell patch-clamp assay in HEK293 cells resulting in an IC<sub>50</sub> of 48 μM<sup>[1]</sup>.
<i><b>In Vivo:</b></i> CZ415 is a highly selective mTOR inhibitor showing in vivo efficacy in a collagen induced arthritis (CIA) model. For full characterization of CZ415 and to enable improved dose predictions, the pharmacokinetic (PK) profile is assessed in rat. PK and oral bioavailability<br><br>
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已为全球多个知名企业、院校构建各种定制型化合物库。</span><br><br>产品链接：<a href="http://www.medchemexpress.cn/CZ415.html">www.medchemexpress.cn/CZ415.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"
src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"
alt="">Purity:98%<BR>MWt:341.3595<BR>Formula:C17H12FN3O2S<BR>SMILES:N#CC1=NN(C2=CC=C(F)C=C2)C(C3=CC=C(S(=O)(C)=O)C=C3)=C1<BR>Pathway:Immunology/Inflammation; <BR>Mechanisms:COX; <BR>Research Area:Inflammation/Immunology<BR>电话： 021-58955995<BR>网址： www.MedChemExpress.cn <BR>地址： 上海市浦东新区蔡伦路720号2号楼3层
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