Etonitazene 是一种高效的选择性 <b>μ</b> 激动剂。<BR><a href="https://www.medchemexpress.cn/EAI045.html">EAI045</a>产品描述：EAI045 is an allosteric inhibitor that targets selected drug-resistant EGFR mutants.
target: EGFR [1]
In vitro: EAI045 potently inhibit EGFR Y1173 phosphorylation in H1975 cells. ( EC50: 2 nM ). [1] EAI045 represents a novel selective inhibitor that can overcome T790M and C797S resistance mutations. [2]
In vivo: EAI045 in combination with cetuximab is effective in mouse models of lung cancer driven by EGFR(L858R/T790M) and by EGFR(L858R/T790M/C797S), a mutant that is resistant to all currently available EGFR TKIs. EAI045 revealed a maximal plasma concentration of 0.57 μM, a half-life of 2.15 h, and oral bioavailability of 26% after dosing at 20 mg/kg.[1] EAI045 markedly reduced tumor growth in a mouse model of L858R/T790M. [2]
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已为全球多个知名企业、院校构建各种定制型化合物库。</span><br><br>产品链接：<a href="http://www.medchemexpress.cn/EAI045.html">www.medchemexpress.cn/EAI045.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"
src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"
alt="">Purity:98%<BR>MWt:396.4827<BR>Formula:C22H28N4O3<BR>SMILES:O=[N+](C1=CC=C2C(N=C(CC3=CC=C(OCC)C=C3)N2CCN(CC)CC)=C1)[O-]<BR>Pathway:GPCR/G Protein; Neuronal Signaling; <BR>Mechanisms:Opioid Receptor; <BR>Research Area:Neurological Disease<BR>电话： 021-58955995<BR>网址： www.MedChemExpress.cn <BR>地址： 上海市浦东新区蔡伦路720号2号楼3层
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