上海皓元生物医药科技有限公司

Saterinone hydrochloride 是磷酸二酯酶 III (<b>PDE III</b>) 抑制剂。<BR><a href="https://www.medchemexpress.cn/TAPI-2.html">TAPI-2</a>产品描述：TAPI-2 is a broad-spectrum inhibitor of matrix metalloprotease (<b>MMP</b>), tumour necrosis factor<i>α</i>-converting enzyme (<b>TACE</b>) and a disintegrin and metalloproteinase (<b>ADAM</b>), with an <b>IC₅₀</b> of 20±10 μM for MMP.

IC50 & Target: IC50: 20±10 μM (MMP)^[1]
Ki: 1.5±0.27 nM (MMPs)^[1]

<i><b>In Vitro:</b></i> The hydroxamate-based metalloprotease inhibitor TAPI-2 bounds to hmeprin with inhibition constants IC₅₀ 20±10 μM for hmeprin <i>β</i> subunit and 1.5±0.27 nM for hmeprin <i>α</i> subunit. Generally, hmeprin <i>α</i> is inhibited more strongly than the β subunit^[1]. Without affecting ADAM17 expression, TAPI-2 dramatically decreases the protein levels of NICD and its downstream target HES-1 in both HCP-1 and HT29 cells. Moreover, treating cells with TAPI-2 significantly decreases the CSC phenotype by -50% in both CRC cell lines. The dose-dependent effects of TAPI-2 on the sphere formation and protein levels of<br><br>
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已为全球多个知名企业、院校构建各种定制型化合物库。</span><br><br>产品链接：<a href="http://www.medchemexpress.cn/TAPI-2.html">www.medchemexpress.cn/TAPI-2.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"

src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"

alt="">Purity:98%<BR>MWt:511.0124<BR>Formula:C27H31ClN4O4<BR>SMILES:N#CC1=CC(C2=CC=C(OCC(O)CN3CCN(C4=CC=CC=C4OC)CC3)C=C2)=C(C)NC1=O.[H]Cl<BR>Pathway:metabolic Enzyme/Protease; <BR>Mechanisms:Phosphodiesterase (PDE); <BR>Research Area:Cardiovascular Disease<BR>电话： 021-58955995<BR>网址： www.MedChemExpress.cn <BR>地址： 上海市浦东新区蔡伦路720号2号楼3层