Losmiprofen 是一种非甾体抗炎镇痛剂。<BR><a href="https://www.medchemexpress.cn/Sufugolix.html">Sufugolix</a>产品描述：Sufugolix (TAK-013) is a highly potent and orally available luteinizing hormone-releasing hormone (<b>LHRH</b>) receptor antagonist with an <b>IC<sub>50</sub></b> of 0.1 nM.
IC50 & Target: IC50: 0.1 nM (human LHRH), 0.6 nM (monkey LHRH)<sup>[1]</sup>
<i><b>In Vitro:</b></i> Sufugolix exhibits more than 3- and 2000-fold selectivity for the human receptor over the monkey and rat receptors, respectively. Sufugolix effectively antagonizes LHRH function on CHO cells expressing the human (IC<sub>50</sub>=0.1 nM) and monkey (IC<sub>50</sub>=0.6 nM) receptors. During the conformational analysis of sufugolix, using high-temperature molecular dynamics calculation, it is observed that the cis conformer of the methoxyurea is more populated than the trans conformer <sup>[1]</sup>.
<i><b>In Vivo:</b></i> Oral administration of sufugolix causes almost complete suppression of the plasma LH levels in castrated male cynomolgus monkeys at a 30 mg/kg dose with sufficient duration of action (more than <br><br>
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已为全球多个知名企业、院校构建各种定制型化合物库。</span><br><br>产品链接：<a href="http://www.medchemexpress.cn/Sufugolix.html">www.medchemexpress.cn/Sufugolix.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"
src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"
alt="">Purity:98%<BR>MWt:318.7516<BR>Formula:C17H15ClO4<BR>SMILES:CC(OC1=CC=CC(C(C2=CC=C(Cl)C=C2)=O)=C1C)C(O)=O<BR>Pathway:Others; <BR>Mechanisms:Others; <BR>Research Area:Inflammation/Immunology<BR>电话： 021-58955995<BR>网址： www.MedChemExpress.cn <BR>地址： 上海市浦东新区蔡伦路720号2号楼3层
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