CP-409092 是 <b>GABA(A)</b> 的部分激动剂，主要用于抗焦虑研究。<BR><a href="https://www.medchemexpress.cn/A-196.html">A-196</a>产品描述：A-196 is a potent and selective chemical inhibitor of SUV420H1 and SUV420H2 that inhibits the di- and trimethylation of H4K20me in multiple cell lines.
Target:
A-196 is a selective chemical probe for SUV420H1/H2. A-196 is the first potent and selective chemical probe for SUV420H1 and SUV420H2. The in vitro activity of A-196 includes inhibition of SUV420H1 with IC50 = 25 nM and SUV420H2 with IC50 = 144 nM for methylation of H4K20me and greater than 100-fold selectivity over other histone methyltransferases and non-epigenetic targets. In cell assays, A-196 inhibits the di- and tri-methylation of H4K20me in multiple cell lines with IC50 < 1 μM. SUV420H1 and SUV420H2 are two highly homologous methyltransferases that di- and tri-methylate 'Lys-20' of histone H4.<br><br>
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已为全球多个知名企业、院校构建各种定制型化合物库。</span><br><br>产品链接：<a href="http://www.medchemexpress.cn/A-196.html">www.medchemexpress.cn/A-196.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"
src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"
alt="">Purity:98%<BR>MWt:297.3517<BR>Formula:C17H19N3O2<BR>SMILES:O=C(C1=CNC2=C1C(CCC2)=O)NC3=CC=C(CNC)C=C3<BR>Pathway:Membrane Transporter/Ion Channel; Neuronal Signaling; <BR>Mechanisms:GABA Receptor; <BR>Research Area:Neurological Disease<BR>电话： 021-58955995<BR>网址： www.MedChemExpress.cn <BR>地址： 上海市浦东新区蔡伦路720号2号楼3层
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