KDR-in-4 是有效的激酶插入结构域受体 (<b>KDR/VEGFR2</b>) 抑制剂，<b>IC<sub>50</sub></b> 值为7 nM。<BR><a href="https://www.medchemexpress.cn/SCH-546738.html">SCH 546738</a>产品描述：SCH 546738 is a novel, potent and non-competitive <b>CXCR3</b> antagonist, the affinity constant (<b>K<sub>i</sub></b>) of SCH 546738 binding to human CXCR3 receptor is determined to be 0.4 nM in multiple experiments.
IC50 & Target: Ki: 0.4 nM (CXCR3 receptor)<sup>[1]</sup>
<i><b>In Vitro:</b></i> The affinity of SCH 546738 binding to human CXCR3 receptor is determined by competition binding analysis using <sup>35</sup>S radiolabeled SCH 535390 (a sulfonamide analog of the CXCR3 compound series with a K<sub>d</sub> of 0.6 nM) as a competitive tracer. In addition, SCH 546738 displaces radiolabeled CXCL10 and CXCL11 from human CXCR3 with IC<sub>50</sub> ranging from 0.8 to 2.2 nM in a non-competitive manner. SCH 546738 potently and specifically inhibits CXCR3-mediated chemotaxis in human activated T cells with IC<sub>90</sub> about 10 nM. Competition of human CXCL10 and CXCL11 binding to human CXCR3 by SCH 546738 is determined at various concentrations of [<sup>125</sup>I]hCXCL10 an<br><br>
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已为全球多个知名企业、院校构建各种定制型化合物库。</span><br><br>产品链接：<a href="http://www.medchemexpress.cn/SCH-546738.html">www.medchemexpress.cn/SCH-546738.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"
src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"
alt="">Purity:98%<BR>MWt:391.4629<BR>Formula:C23H25N3O3<BR>SMILES:O=C1NC2=C(C=CC=C2)C=C1C(N3)=CC4=C3C=CC(OCCN(CCOC)C)=C4<BR>Pathway:Protein Tyrosine Kinase/RTK; <BR>Mechanisms:VEGFR; <BR>Research Area:Cardiovascular Disease<BR>电话： 021-58955995<BR>网址： www.MedChemExpress.cn <BR>地址： 上海市浦东新区蔡伦路720号2号楼3层
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