ABT-639 hydrochloride 是一种新型选择性的 T 型 <b>Ca<sup>2+</sup></b> 通道阻滞剂。<BR><a href="https://www.medchemexpress.cn/Taranabant.html">Taranabant</a>产品描述：Taranabant is a highly potent and selective <b>cannabinoid 1</b> (<b>CB1</b>) receptor inverse agonist that inhibits the binding and functional activity of various agonists, with a binding <b>K<sub>i</sub></b> of 0.13 nM for the human CB1R in vitro.
IC50 & Target: IC50: 0.3 nM (hCB1R), 0.4 nM (rCB1R)<sup>[1]</sup><br/>Ki: 0.13 nM (hCB1R), 0.27 nM (rCB1R)<sup>[1]</sup>
<i><b>In Vitro:</b></i> Taranabant (MK-0364) binds to human or rat CB1R with an IC<sub>50</sub> of 0.3 and 0.4 nM, respectively, corresponding to a K<sub>i</sub> value of 0.13 and 0.27 nM, respectively. Taranabant binds to the human or rat CB2R with an IC<sub>50</sub> value of 290 and 470 nM, respectively, corresponding to a K<sub>i</sub> value of 170 and 310 nM, respectively. The selectivity ratio of CB1R over CB2R is approximately 1000-fold<sup>[1]</sup>. Taranabant (MK-0364) is a novel, acyclic cannabinoid-1 receptor inverse agonist for the treatment of obesity. IC<sub>50</sub>s of Taranabant for CB1R and CB2R by <br><br>
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已为全球多个知名企业、院校构建各种定制型化合物库。</span><br><br>产品链接：<a href="http://www.medchemexpress.cn/Taranabant.html">www.medchemexpress.cn/Taranabant.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"
src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"
alt="">Purity:98%<BR>MWt:492.3668<BR>Formula:C20H21Cl2F2N3O3S<BR>SMILES:O=S(C1=CC(C(N2C[C@](CCC3)([H])N3CC2)=O)=C(Cl)C=C1F)(NC4=CC=CC=C4F)=O.Cl<BR>Pathway:Membrane Transporter/Ion Channel; <BR>Mechanisms:Calcium Channel; <BR>Research Area:Neurological Disease<BR>电话： 021-58955995<BR>网址： www.MedChemExpress.cn <BR>地址： 上海市浦东新区蔡伦路720号2号楼3层
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