SPD-473 citrate 是 5-HT/多巴胺/去甲肾上腺素再摄取抑制剂。<BR><a href="https://www.medchemexpress.cn/AZD-5438.html">AZD-5438</a>产品描述：AZD-5438 is a potent inhibitor of <b>CDK1/2/9</b> with <b>IC<sub>50</sub></b> of 16 nM/6 nM/20 nM in cell-free assays. It also inhibits GSK3β, but is less potent to CDK5/6.
IC50 & Target: IC50: 16 nM (CDK1), 6 nM (CDK2), 20 nM (CDK9)
<sup>[1]</sup>
<i><b>In Vitro:</b></i> AZD5438 potently inhibits the kinase activity of cyclin E-cdk2, cyclin A-cdk2, cyclin B1-cdk1, p25-cdk5, cyclin D3-cdk6, and cyclin T-cdk9 (IC<sub>50</sub>, 6, 45, 16, 21, and 20 nM, respectively). AZD5438 potently inhibits the kinase activity of cyclin E-cdk2, cyclin A-cdk2, cyclin B1-cdk1, p25-cdk5, cyclin D3-cdk6, and cyclin T-cdk9 (IC<sub>50</sub>, 6, 45, 16, 21, and 20 nM, respectively). In common with many other cdk inhibitors, AZD5438 also inhibits the kinase activity of p25-cdk5 and glycogen synthase kinase 3β in vitro (IC<sub>50</sub>, 14 and 17 nM, respectively)<sup>[1]</sup>. AZD5438 significantly augments cellular radiosensitivity in NSCLC cells. Combined treatment with AZD5438 and irradiation also enha<br><br>
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已为全球多个知名企业、院校构建各种定制型化合物库。</span><br><br>产品链接：<a href="http://www.medchemexpress.cn/AZD-5438.html">www.medchemexpress.cn/AZD-5438.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"
src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"
alt="">Purity:98%<BR>MWt:552.4651<BR>Formula:C23H31Cl2NO8S<BR>SMILES:CN(CCCSCC(C1(C2=CC=C(Cl)C(Cl)=C2)CCC1)=O)C.O=C(CC(C(O)=O)(O)CC(O)=O)O<BR>Pathway:Neuronal Signaling; <BR>Mechanisms:Dopamine Transporter; Serotonin Transporter; <BR>Research Area:Neurological Disease<BR>电话： 021-58955995<BR>网址： www.MedChemExpress.cn <BR>地址： 上海市浦东新区蔡伦路720号2号楼3层
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