Manitimus 是一种 dehydroorotate dehydrogenase 的抑制剂，同时为有效的免疫抑制药。<BR><a href="https://www.medchemexpress.cn/SCH-563705.html">SCH 563705</a>产品描述：SCH 563705 is a potent dual CXCR2(IC50= 1.3 nM)/CXCR1(IC50= 7.3 nM) antagonist.
IC50 value: 7.3 nM (CXCR1); 1.3 nM (CXCR2) [1]
Target: CXCR1; CXCR2
in vitro: SCH 563705 has emerged as the most potent CXCR2–CXCR1 dual antagonist to date. It has been evaluated further in a wide range of in vitro and in vivo studies. In the chemotaxis assays, it demonstrated potent inhibition against both Gro-α and IL-8 induced human neutrophil migration (chemotaxis IC50 = 0.5 nM, against 30 nM of Gro-α; chemotaxis IC50 = 37 nM, against 3 nM of IL-8) [1]. SCH563705 selectively reduced the peripheral blood neutrophil frequency, and caused an elevation in the CXCR2 ligand CXCL1 [2].
in vivo: SCH 563705 achieved an ED50 of 0.9 mg/kg in the rat LPS (lipopolysaccharide) challenged model and an ED50 of 1 mg/kg in the mouse cigarette smoke induced neutrophilic inflammatory model [1].<br><br>
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已为全球多个知名企业、院校构建各种定制型化合物库。</span><br><br>产品链接：<a href="http://www.medchemexpress.cn/SCH-563705.html">www.medchemexpress.cn/SCH-563705.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"
src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"
alt="">Purity:98%<BR>MWt:308.2552<BR>Formula:C15H11F3N2O2<BR>SMILES:C#CCC/C(O)=C(C#N)/C(NC1=CC=C(C(F)(F)F)C=C1)=O<BR>Pathway:Others; <BR>Mechanisms:Others; <BR>Research Area:Inflammation/Immunology<BR>电话： 021-58955995<BR>网址： www.MedChemExpress.cn <BR>地址： 上海市浦东新区蔡伦路720号2号楼3层
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