Aligeron是一种非选择性的<b>prostaglandin (PG)</b>拮抗剂，具有舒张血管的作用。<BR><a href="https://www.medchemexpress.cn/Ko-143.html">Ko 143</a>产品描述：Ko 143 is a practical breast cancer resistance protein multidrug transporter inhibitor <b>BCRP</b>, with the <b>EC<sub>90</sub></b> value of 26 nM.
IC50 & Target: EC90: 26 nM (BCRP)
<i><b>In Vitro:</b></i> Ko143 (10 nM) significantly decreases (2.5-fold) the IC<sub>50</sub> of MTX for HEK G2 cells and mouse G2 cells. Ko143 (1-100 μM) metabolite does not inhibit the function of ABC Transporters<sup>[1]</sup>. Reversal of drug resistance in topotecan-selected mouse MEF3.8/T6400 cells and human IGROV1/T8 cells by FTC analogue Ko143. Ko143 is applied at zero, one, or eight times the EC<sub>90</sub> concentration of 25 nM<sup>[2]</sup>. Ko143 inhibits BCRP-mediated transport of rosuvastatin in Madin-Darby Canine Kidney (MDCK) 2-BCRP421CC (wild type) cells and MDCK2-BCRP421AA (mutant type) cells<sup>[3]</sup>.
<i><b>In Vivo:</b></i> Ko143 (10 mg/kg, p.o.) increases the oral availability of topotecan in mice<sup>[2]</sup>. Ko143 significantly affects the pharmacokinetics of rosuvastatin i<br><br>
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已为全球多个知名企业、院校构建各种定制型化合物库。</span><br><br>产品链接：<a href="http://www.medchemexpress.cn/Ko-143.html">www.medchemexpress.cn/Ko-143.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"
src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"
alt="">Purity:98%<BR>MWt:292.4180<BR>Formula:C20H24N2<BR>SMILES:C=CCN1CCN(C(C2=CC=CC=C2)C3=CC=CC=C3)CC1<BR>Pathway:GPCR/G Protein; <BR>Mechanisms:Prostaglandin Receptor; <BR>Research Area:Cardiovascular Disease<BR>电话： 021-58955995<BR>网址： www.MedChemExpress.cn <BR>地址： 上海市浦东新区蔡伦路720号2号楼3层
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