上海皓元生物医药科技有限公司

Bamirastine 抑制配体结合到重组人组胺 H₁ 受体 (<b>rhH₁R</b>)，<b>IC₅₀</b> 为 17.3 nM。<BR><a href="https://www.medchemexpress.cn/Semagacestat.html">Semagacestat</a>产品描述：Semagacestat is a <b>γ-secretase</b> inhibitor, inhibits <b>β-amyloid</b> (<b>Aβ42</b>), <b>Aβ38</b> and <b>Aβ40</b> with <b>IC₅₀</b> of 10.9, 12 and 12.1 nM, respectively; also inhibits <b>Notch</b> signaling with <b>IC₅₀</b> of 14.1 nM.
IC50 & Target: IC50: 10.9 nM (Aβ42), 12 nM (Aβ38), 12.1 nM (Aβ40), 14.1 nM (Notch)^[1]
<i><b>In Vitro:</b></i> Semagacestat (LY450139) reduces the secretion of Aβ42, Aβ40, and Aβ38 in 96-well-cultured media and increases β-CTF in cell lysates as expected, although this increase is unexpectedly attenuated at high concentrations^[1]. In cortical neurons (CTX), Semagacestat (LY450139) causes a concentration-dependent decrease in Aβ40 secreted into the medium with IC₅₀ value 111 nM for Semagacestat. Semagacestat causes a concentration-dependent decrease in Aβ40 and Aβ42 secreted into the medium with an IC₅₀ value of 126 and 130 nM, respectively^[2].
<i><b>In Vivo:</b></i> Semag<br><br>
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<span style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial , sans-serif;font-size: 11.818182px;background-color: rgb(251,251,251);">公司介绍：MedChemExpress(MCE)专注于各种抑制剂、激动剂、API及化合物库，总部位于美国新泽西，分别在瑞典和上海设有欧洲区子公司和亚洲区总代理，营销网点遍及全球20多个国家地区。MCE经过多年努力已成为全球生物活性小分子领域的一流供应商， 产品涵盖癌症、神经科学、抗感染、表观遗传学等20个热门研究领域，PI3K、MAPK等近千个细分靶点，超过4000个活性小分子化合物现货，以及GPCR、API、离子通道等超过20种不同类型的化合物库，同时提供从毫克到千克的专业定制合成服务。</span>
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已为全球多个知名企业、院校构建各种定制型化合物库。</span><br><br>产品链接：<a href="http://www.medchemexpress.cn/Semagacestat.html">www.medchemexpress.cn/Semagacestat.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"

src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"

alt="">Purity:98%<BR>MWt:527.6572<BR>Formula:C31H37N5O3<BR>SMILES:O=C(O)C(C)(C)C1=CN2N=C(NCCCN3CCC(OC(C4=CC=CC=C4)C5=CC=CC=C5)CC3)C=CC2=N1<BR>Pathway:GPCR/G Protein; Immunology/Inflammation; <BR>Mechanisms:Histamine Receptor; <BR>Research Area:Inflammation/Immunology<BR>电话： 021-58955995<BR>网址： www.MedChemExpress.cn <BR>地址： 上海市浦东新区蔡伦路720号2号楼3层