上海皓元生物医药科技有限公司

Ethyl dirazepate是一种苯并二氮杂衍生物。具有抗焦虑和催眠特性。<BR><a href="https://www.medchemexpress.cn/NPS-2143.html">NPS-2143</a>产品描述：NPS-2143 is a novel potent and selective antagonist of <b>Ca²⁺ receptor</b> with <b>IC₅₀</b> of 43 nM.
IC50 & Target: IC50: 43 nM (Ca²⁺ receptor)
<i><b>In Vitro:</b></i> NPS-2143 blocks increases in cytoplasmic Ca²⁺ concentrations with IC₅₀ of 43 nM elicited by activating the Ca²⁺ receptor in HEK 293 cells expressing the human Ca²⁺ receptor. NPS-2143 stimulates parathyroid hormone (PTH) secretion from bovine parathyroid cells with EC₅₀ of 41 nM. Moreover, NPS 214 also blocks the inhibitory effects of calcimimetic NPS R-467 on PTH secretion from bovine parathyroid cells and the inhibitory effects of extracellular Ca²⁺ on isoproterenol-stimulated increases in cyclic AMP formation^[1]. In HEK-293 cells transiently expressing hCaSRs, NPS-2143 significantly suppresses the kokumi taste by effectively inhibiting the activity of both GSH and γ-Glu-Val-Gly^[3]. A recent stud<br><br>
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已为全球多个知名企业、院校构建各种定制型化合物库。</span><br><br>产品链接：<a href="http://www.medchemexpress.cn/NPS-2143.html">www.medchemexpress.cn/NPS-2143.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"

src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"

alt="">Purity:98%<BR>MWt:377.2214<BR>Formula:C18H14Cl2N2O3<BR>SMILES:O=C(C1C(NC2=CC=C(Cl)C=C2C(C3=CC=CC=C3Cl)=N1)=O)OCC<BR>Pathway:Others; <BR>Mechanisms:Others; <BR>Research Area:Neurological Disease<BR>电话： 021-58955995<BR>网址： www.MedChemExpress.cn <BR>地址： 上海市浦东新区蔡伦路720号2号楼3层