RPH-2823 是一种氨苯蝶啶衍生物，具有利尿的作用。
<BR><a href="https://www.medchemexpress.cn/Flavopiridol-Hydrochloride.html">Flavopiridol (Hydrochloride)</a>产品描述：Flavopiridol hydrochloride competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective for CDK1/2/4/6 than CDK7. Flavopiridol is initially found to inhibit EGFR and PKA.
IC50 Value: ~ 40 nM
Target: CDK
in vitro: Flavopiridol induces G1 arrest with inhibition of CDK2 and CDK4 in human breast carcinoma cells in a time and concentration dependent manner. Short time treatment of Flavopiridol (~12 hours) induce apoptosis in hematopoietic cell lines including SUDHL4, SUDHL6 (B-cell lines), Jurkat and MOLT4 (T-cell lines ), and HL60 (myeloid). In the clonogenic assay, Flavopiridol functions as a highly potent cytotoxic compound with a mean IC70 with 8 ng/mL in 23 human tumor models. A recent study shows Flavopiridol treatment induces a substantial AKT-Ser473 phosphorylation in human glioblastoma T98G cell line.
in vivo: After treatment with 7.5 mg/kg Flavopiridol bolus intravenous (IV) or intraperitoneal on each of 5 consecuti<br><br>
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已为全球多个知名企业、院校构建各种定制型化合物库。</span><br><br>产品链接：<a href="http://www.medchemexpress.cn/Flavopiridol-Hydrochloride.html">www.medchemexpress.cn/Flavopiridol-Hydrochloride.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"
src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"
alt="">Purity:98%<BR>MWt:370.4090<BR>Formula:C17H22N8O2<BR>SMILES:OC(COC1=CC=C(C2=NC3=C(N)N=C(N)N=C3N=C2N)C=C1)CN(C)C<BR>Pathway:Others; <BR>Mechanisms:Others; <BR>Research Area:Others<BR>电话： 021-58955995<BR>网址： www.MedChemExpress.cn <BR>地址： 上海市浦东新区蔡伦路720号2号楼3层
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