2614W94是具有选择性的，可逆的<b>monoamine oxidase-A</b>抑制剂，<b>IC<sub>50</sub></b>值和<b>K<sub>i</sub></b>值分别为5 nM和1.6 nM。<BR><a href="https://www.medchemexpress.cn/Bay_41-4109.html">Bay 41-4109</a>产品描述：BAY 41-4109 is a potent inhibitor of human hepatitis B virus (<b>HBV</b>) with an <b>IC<sub>50</sub></b> of 53 nM.
IC50 & Target: IC50&Target: 53 nM (HBV)<sup>[1]</sup>
<i><b>In Vitro:</b></i> BAY 41-4109 is able to both accelerate and misdirect capsid assembly <i>in vitro</i>. Preformed capsids are stabilized by BAY 41-4109, up to a ratio of one inhibitor molecule per two dimers<sup>[2]</sup>. BAY 41-4109 is equally effective at inhibiting HBV DNA release and the cytoplasmic HBcAg level, with IC<sub>50</sub>s of 32.6 and 132 nM in HepG2.2.15 cells, respectively. HBV DNA and HBcAg are inhibited in a dose-dependent manner, indicating that the anti-HBV mechanisms are associated with and dependent on the rate of HBcAg inhibition<sup>[3]</sup>.
<i><b>In Vivo:</b></i> BAY 41-4109 reduces viral DNA in the liver and in the plasma dose-dependently with efficacy comparable to 3TC. BAY 41 -4109 reduces hepatitis B virus core antigen (HBcAg) in livers of HBV-transgenic mice. Pharmacokineti<br><br>
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<span style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial , sans-serif;font-size: 11.818182px;background-color: rgb(251,251,251);">公司介绍：MedChemExpress(MCE)专注于各种抑制剂、激动剂、API及化合物库，总部位于美国新泽西，分别在瑞典和上海设有欧洲区子公司和亚洲区总代理，营销网点遍及全球20多个国家地区。MCE经过多年努力已成为全球生物活性小分子领域的一流供应商， 产品涵盖癌症、神经科学、抗感染、表观遗传学等20个热门研究领域，PI3K、MAPK等近千个细分靶点，超过4000个活性小分子化合物现货，以及GPCR、API、离子通道等超过20种不同类型的化合物库，同时提供从毫克到千克的专业定制合成服务。</span>
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已为全球多个知名企业、院校构建各种定制型化合物库。</span><br><br>产品链接：<a href="http://www.medchemexpress.cn/Bay_41-4109.html">www.medchemexpress.cn/Bay_41-4109.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"
src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"
alt="">Purity:98%<BR>MWt:344.3056<BR>Formula:C15H11F3O4S<BR>SMILES:CC(OC(C=C1OC2=C3C=CC=C2)=CC=C1S3(=O)=O)C(F)(F)F<BR>Pathway:Neuronal Signaling; <BR>Mechanisms:Monoamine Oxidase; <BR>Research Area:Neurological Disease<BR>电话： 021-58955995<BR>网址： www.MedChemExpress.cn <BR>地址： 上海市浦东新区蔡伦路720号2号楼3层
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