Bencianol 是一种半合成的黄酮类化合物，具有止痉挛的功效。<BR><a href="https://www.medchemexpress.cn/eFT508.html">eFT508</a>产品描述：eFT508 is a potent, highly selective, and orally bioavailable <b>MNK1</b> and <b>MNK2</b> inhibitor, with <b>IC<sub>50</sub></b> of 1-2 nM against both of the two isoforms.
IC50 & Target: IC50: 1-2 nM (MNK1), 1-2 nM (MNK2)<sup>[1]</sup>
<i><b>In Vitro:</b></i> eFT508 reduces eIF4E phosphorylation dose-dependently at serine 209 (IC<sub>50</sub>=2-16 nM) in tumor cell lines. In a panel of appr 50 hematological cancers, eFT508 shows anti-proliferative activity against multiple DLBCL cell lines. Sensitivity to eFT508 in TMD8, OCI-Ly3 and HBL1 DLBCL cell lines is associated with dose-dependent decreases in production of pro-inflammatory cytokines including TNFα, IL-6, IL-10 and CXCL10. Further evaluation eFT508 mechanism of action demonstrates that decreased TNFα production correlates with a 2-fold decrease in TNFα mRNA half-life<sup>[1]</sup>.
<i><b>In Vivo:</b></i> eFT508 shows significant anti-tumor activity in the TMD8 and HBL-1 ABC-DLBCL models, both of which harbor activating MyD8<br><br>
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已为全球多个知名企业、院校构建各种定制型化合物库。</span><br><br>产品链接：<a href="http://www.medchemexpress.cn/eFT508.html">www.medchemexpress.cn/eFT508.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"
src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"
alt="">Purity:98%<BR>MWt:454.4707<BR>Formula:C28H22O6<BR>SMILES:O[C@@H]1[C@@H](C2=CC=C(OC(C3=CC=CC=C3)(C4=CC=CC=C4)O5)C5=C2)OC6=CC(O)=CC(O)=C6C1<BR>Pathway:Others; <BR>Mechanisms:Others; <BR>Research Area:Neurological Disease<BR>电话： 021-58955995<BR>网址： www.MedChemExpress.cn <BR>地址： 上海市浦东新区蔡伦路720号2号楼3层
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