sulfo-SPDB-DM4 是 ADC 的一部分，由 maytansinebased payload (DM4) 与 sulfo-SPDB 连接而成。<BR><a href=""https://www.medchemexpress.cn/AZD0156.html"">AZD0156</a>产品描述：AZD0156 is an orally active, potent and selective <b>ATM kinase</b> inhibitor, used for cancer treatment.
<i><b>In Vitro:</b></i> AZD0156 inhibits the kinase activity of ATM and ATM-mediated signaling, prevents DNA damage checkpoint activation, and disrupts DNA damage repair, inducs tumor cell apoptosis, and leads to cell death in ATM-overexpressing tumor cells<sup>[1]</sup>.
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<span style=""outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);font-family: ""Helvetica Neue"" , Helvetica , Arial , sans-serif;font-size: 11.818182px;background-color: rgb(251,251,251);"">公司介绍：MedChemExpress(MCE)专注于各种抑制剂、激动剂、API及化合物库，总部位于美国新泽西，分别在瑞典和上海设有欧洲区子公司和亚洲区总代理，营销网点遍及全球20多个国家地区。MCE经过多年努力已成为全球生物活性小分子领域的一流供应商， 产品涵盖癌症、神经科学、抗感染、表观遗传学等20个热门研究领域，PI3K、MAPK等近千个细分靶点，超过4000个活性小分子化合物现货，以及GPCR、API、离子通道等超过20种不同类型的化合物库，同时提供从毫克到千克的专业定制合成服务。</span>
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已为全球多个知名企业、院校构建各种定制型化合物库。</span><br><br>产品链接：<a href=""http://www.medchemexpress.cn/AZD0156.html"">www.medchemexpress.cn/AZD0156.html</a><br><br></span><img style=""width: 600.0px;height: 310.0px;""
src=""http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg""
alt="""">Purity:98%<BR>MWt:1075.6570<BR>Formula:C46H63ClN4O17S3<BR>SMILES:C[C@]1([C@@](CC(N(C(C=C2C=C3OC)=C3Cl)C)=O)([H])OC([C@H](C)N(C)C(CCC(C)(C)SSCCC(S(=O)(O)=O)C(ON(C4=O)C(CC4)=O)=O)=O)=O)[C@H]([C@@H]([C@](OC5=O)([H])C[C@]([C@](/C=C/C=C(C)/C2)([H])OC)(N5)O)C)O1<BR>Pathway:Antibody-drug Conjugate/ADC Related; <BR>Mechanisms:Drug-linker Conjugates for ADC; <BR>Research Area:Cancer<BR>电话： 021-58955995<BR>网址： www.MedChemExpress.cn <BR>地址： 上海市浦东新区蔡伦路720号2号楼3层
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