BRCA1-IN-1 是一种新型的小分子 <b>BRCA1</b> 抑制剂，<b>IC<sub>50</sub></b> 和 <b>K<sub>i</sub></b> 分别为 0.53 μM 和 0.71 μM。<BR><a href="https://www.medchemexpress.cn/CBR-5884.html">CBR-5884</a>产品描述：CBR-5884 is a novel and noncompetitive 3-Phosphoglycerate dehydrogenase (PHGDH) inhibitor with IC50=33 μM). Decreases de novo serine synthesis in cancer cells. Inhibits proliferation of cancer cell lines and disrupted the oligomerization state of PHGDH.
Biochemical characterization of the inhibitor revealed that it was a noncompetitive inhibitor that showed a time-dependent onset of inhibition and disrupted the oligomerization state of PHGDH. The identification of a small molecule inhibitor of PHGDH not only enables thorough preclinical evaluation of PHGDH as a target in cancers, but also provides a tool with which to study serine metabolism. [1]
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已为全球多个知名企业、院校构建各种定制型化合物库。</span><br><br>产品链接：<a href="http://www.medchemexpress.cn/CBR-5884.html">www.medchemexpress.cn/CBR-5884.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"
src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"
alt="">Purity:98%<BR>MWt:578.5447<BR>Formula:C27H33F2N4O6P<BR>SMILES:O=C(N[C@@H](CC(F)(F)P(O)(O)=O)C(NCC(NCCCCC1=CC=CC=C1)=O)=O)CCC2=CNC3=C2C=CC=C3<BR>Pathway:Cell Cycle/DNA Damage; Epigenetics; <BR>Mechanisms:PARP; <BR>Research Area:Cancer<BR>电话： 021-58955995<BR>网址： www.MedChemExpress.cn <BR>地址： 上海市浦东新区蔡伦路720号2号楼3层
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