上海皓元生物医药科技有限公司

(R)-GNE-140 是一种有效的 <b>LDHA</b> 抑制剂，对 LDHA 和 LDHB 的 <b>IC₅₀</b> 值分别为 3 nM 和 5 nM；(R)-GNE-140 的活性是 S 型异构体的 18 倍。<BR><a href="https://www.medchemexpress.cn/Calcipotriol.html">Calcipotriol</a>产品描述：Calcipotriol is a synthetic VitD₃ analogue with a high affinity for the <b>vitamin D</b> receptor.
IC50 & Target: Vitamin D receptor^[1]
<i><b>In Vitro:</b></i> When NHEK cells are not stimulated with IL-17A or IL-22, Calcipotriol slightly enhances (0.2 nM) IL-8 mRNA expression or has no effect (2-20 nM). The addition of IL-17A and IL-22 markedly increased the mRNA expression of IL-8, confirming our previous study. This enhanced IL-8 mRNA expression is suppressed by Calcipotriol at 2, 20 and 40 nM in a dose dependent manner^[1]. Treatment of natural killer (NK) cells with drugs modulates their expression of NK cytotoxicity receptors or KIR. Human NK cells are pre-treated with 100, 10 or 1 ng/mL of 1,25(OH)₂D3, Calcipotriol or FTY720 for 4 h. All three concentrations of 1,25(OH)₂D3, Calcipotriol and FTY720 significantly up-regulate the expression of NKp30 on the surface of NK cells after 4 h incubation<sup>[2]<br><br>
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已为全球多个知名企业、院校构建各种定制型化合物库。</span><br><br>产品链接：<a href="http://www.medchemexpress.cn/Calcipotriol.html">www.medchemexpress.cn/Calcipotriol.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"

src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"

alt="">Purity:98%<BR>MWt:499.0447<BR>Formula:C25H23ClN2O3S2<BR>SMILES:O=C1N[C@@](C2=CSC=C2)(C3=CC=C(N4CCOCC4)C=C3)CC(O)=C1SC5=CC=CC=C5Cl<BR>Pathway:metabolic Enzyme/Protease; <BR>Mechanisms:Lactate Dehydrogenase; <BR>Research Area:Cancer<BR>电话： 021-58955995<BR>网址： www.MedChemExpress.cn <BR>地址： 上海市浦东新区蔡伦路720号2号楼3层