Roflumilast Impurity E是Roflumilast的杂质。Roflumilast（Daliresp）是一种药物，对<b>PDE-4</b>有选择性长效抑制作用，<b>IC<sub>50</sub></b>值为0.8 nM。<BR><a href="https://www.medchemexpress.cn/MRT68921-hydrochloride.html">MRT68921 (hydrochloride)</a>产品描述：MRT68921 hydrochloride is the most potent inhibitor of both ULK1 and ULK2, with greater than a 15-fold reduction in the IC50 for ULK1 (2.9 nM) and greater than a 30-fold reduction for ULK2 (1.1 nM).
IC50 value: 2.9/1.1 nM (ULK1/2)
Target: ULK
in vitro: MRT68921 potently inhibits ULK1 and ULK2 and block autophagy in cells. MRT68921 specifically blocks autophagic flux through ULK1 inhibition. MRT68921 is able to inhibit the WT-restored ATG13 phosphorylation and autophagy similarly to cells expressing endogenous ULK1. [1]<br><br>
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已为全球多个知名企业、院校构建各种定制型化合物库。</span><br><br>产品链接：<a href="http://www.medchemexpress.cn/MRT68921-hydrochloride.html">www.medchemexpress.cn/MRT68921-hydrochloride.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"
src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"
alt="">Purity:98%<BR>MWt:349.1170<BR>Formula:C13H8Cl2F2N2O3<BR>SMILES:O=C(NC1=C(Cl)C=NC=C1Cl)C2=CC=C(OC(F)F)C(O)=C2<BR>Pathway:metabolic Enzyme/Protease; <BR>Mechanisms:Phosphodiesterase (PDE); <BR>Research Area:Inflammation/Immunology<BR>电话： 021-58955995<BR>网址： www.MedChemExpress.cn <BR>地址： 上海市浦东新区蔡伦路720号2号楼3层
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