SHP099是有效选择性，有口服活性的<b>SHP2</b>抑制剂，<b>IC<sub>50</sub></b>值为70 nM。<BR><a href="https://www.medchemexpress.cn/Fumarate-hydratase-IN-2-sodium-salt.html">Fumarate hydratase-IN-2 (sodium salt)</a>产品描述：.Fumarate hydratase is an enzyme of the TCA cycle and cell-permeable inhibitors
(1) inhibition of fumarate hydratase can contribute to tumorigenicity in some cells.
(2) The use of a photoaffinity labeling strategy identified fumarate hydratase as the principal pharmacological target. Final biochemical studies confirmed dose-dependent, competitive inhibition of this enzyme
(3) Chemical inhibition of fumarate hydratase renders cells highly dependent on glucose metabolism for survival.
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已为全球多个知名企业、院校构建各种定制型化合物库。</span><br><br>产品链接：<a href="http://www.medchemexpress.cn/Fumarate-hydratase-IN-2-sodium-salt.html">www.medchemexpress.cn/Fumarate-hydratase-IN-2-sodium-salt.html</a><br><br></span><img style="width: 600.0px;height: 310.0px;"
src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"
alt="">Purity:98%<BR>MWt:352.2616<BR>Formula:C16H19Cl2N5<BR>SMILES:NC1=NC(N2CCC(C)(N)CC2)=CN=C1C3=CC=CC(Cl)=C3Cl<BR>Pathway:Protein Tyrosine Kinase/RTK; <BR>Mechanisms:Discoidin Domain Receptor; <BR>Research Area:Cancer<BR>电话： 021-58955995<BR>网址： www.MedChemExpress.cn <BR>地址： 上海市浦东新区蔡伦路720号2号楼3层
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